Protein Function

Cell Cycle Protein Identification: Identification of cell cycle control proteins through homology transfer and machine learning techniques. We use database mining, literature searches and evolutionary conservation estimates to provide genome-wide annotations for cell cycle control proteins. We have also developed a SVM method to complement homology-transfer in the identification of cell cycle kinases from sequence alone.

Cell Cycle Kinase Identification: Using information from highly conserved and semi-exposed protein residues from cell cycle kinases we are able to classify kinases involved in this specific biological pathway. We show the ability to correctly predict kinases involved in the cell cycle from all kinases by using a superset of highly conserved and semi-exposed residues. These residues, many of which reside in the nucleotide binding site of the enzymes, represent a majority of the functionally significant residues of the kinases and lead us towards their specific cell cycle functional classification.