Protein-Protein Interaction

PiNat is a platform for assessing protein-protein interaction networks. The platform integrates information about protein function and sub-cellular localization and outputs the reliable interactions involving the query proteins. The interactions are rendered as an image in the cellular context and can help elucidate biological pathways and processes. We have used the system to analyze proteins implicated with Alzheimer's disease and shown how the integrated view corroborates previous observations and helps formulate new hypotheses regarding the molecular underpinnings of the disease.